Some big names will be looking to continue their magnificent form from the international games, while others, who didn't take part, will be fully rested ahead of this weekend's fixtures. Here are three players who could shine this weekend.
Manchester United v Leicester City (Sat 3pm BST) – Jamie Vardy to score first @ 6/1
Vardy's season really got kickstarted last time out when Leicester beat Bournemouth 3-1 last month.
He scored twice and generally terrorised the Cherries defence to take his tally for the season to three goals.
Despite being 32-years-old and his game being reliant on pace, the former Premier League winner is showing no signs of slowing down and is still a menacing prospect to play against.
He is set to come up against Manchester United on Saturday, a team he enjoys playing against, scoring five goals in nine games including the record-breaking strike in that famous season which saw him score in 11 consecutive Premier League games.
United are still a slightly shaky prospect at the back and Vardy will have the advantage of coming up against ex-team mate Harry Maguire, someone who's game he knows extremely well.
Maguire's international break ended on a bad note after giving a penalty away against Kosovo, while Vardy did not play and is fit and fresh – a situation he will relish.
Norwich v Manchester City (Sat 5:30pm BST) – Teemu Pukki to score anytime @ 5/2
First things first, City are such a devastating prospect that they will probably win this one, but that doesn't mean they don't come into the game with problems of their own.
Aymeric Laporte is out injured for the foreseeable future while there are doubts about John Stones' fitness, leaving just one natural central defensive option in Nicolas Otamendi.
That could open the door for Pukki, who has scored five goals in the Premier League already this season.
He is also Finland's talisman and scored in both their games over the international period, as they defeated Greece and lost to Italy.
Pukki's movement is first class and if City have to resort to playing some like Fernandinho at centre-back, for example, then the 29-year-old could profit.
Bournemouth v Everton (Sun 2pm BST) – Richarlison to score anytime @ 21/10
Usually a fast starter to a new season, Richarlison grabbed his first two Premier League goals against Wolves last time out.
He was excellent in the game at Goodison Park, scoring a clever flicked header towards the far corner to win the match.
Bournemouth, as any fan of the Premier League knows, like to attack and they are happy to sacrifice a bit of defensive solidity to get goals.
With the Brazilian's name now on the scoresheet this season, expect him to come close again when they face a Cherries side that has yet to keep a clean sheet in the league.