The likes of Watford, Wolves, Norwich and Aston Villa will look to improve their fortunes, while Liverpool will be aiming to make it five wins from as many matches.
But for this weekend we are looking for the value bets, and three games take our fancy.
Manchester United vs Leicester City – Leicester to win @ 18/5
The Foxes are a great price this weekend as they prepare to travel to Old Trafford on Saturday afternoon. Brendan Rodgers' troops are unbeaten so far this season, and that form has moved them into third in the table.
Leicester are just for points behind league leaders Liverpool, and they have shown signs of real promise this term. Jamie Vardy has found his rhythm in front of goal, while Caglar Soyuncu has replaced Harry Maguire with ease.
United are eighth after an inconsistent start to the campaign but a win this weekend would see them climb above the Foxes.
The Red Devils do have injury worries though, with Paul Pogba, Anthony Martial and Aaron Wan-Bissaka all doubts.
Tottenham vs Crystal Palace – Crystal Palace to win 9/1
Palace have defied the odds this season to climb into fourth, with their win over Manchester United catching the eye. Roy Hodgson's men have won their last two matches in the top flight, and their price looks simply too big for those hunting value.
Spurs have been poor to date, with their only win coming against Aston Villa. They have lost three of their last five matches at home and are without Giovani Lo Celso due to injury.
Wolves vs Chelsea – Chelsea to win 17/11
Chelsea are worth backing this weekend as they try to add to Wolves' misery this season. Despite excelling Nuno Espirito Santo's side have yet to win a Premier League game this season, with their only points coming from three draws.
While Chelsea have not been at their best, they are still unbeaten in their last three matches.
Frank Lampard seems to be getting the best out of Tammy Abraham, Mason Mount and Mateo Kovacic and the Blues have enough quality to get past Wolves at Molineux.