Newcastle United pulled off a shock win on Sunday as they beat Tottenham Hotspur 1-0, while Crystal Palace also managed to stun Manchester United at Old Trafford.
With the top flight now in full swing, we take a look at some more bets with potentially huge returns.
Southampton to beat Manchester United @ 10/3
The Saints got off the mark last weekend as they beat Brighton 2-0 at the AMEX Stadium. Ralph Hasenhuttl's men were clinical on the south coast last weekend and their victory seems to have given everyone a lift.
A much-changed Southampton side beat Fulham on Tuesday in the Carabao Cup and Hasenhuttl's outfit have now secured back-to-back clean sheets.
While United made a good start to the season, they have now not won in two and their defeat to Palace proved the Red Devils are far from the finished article.
Norwich to beat West Ham @ 31/10
Just one point separates the two sides in the early Premier League table but it is West Ham that have the advantage after picking up four points in the last two weeks.
Their win over Watford raised a few eyebrows and they followed that up with progression in the Carabao Cup against Newport County.
Norwich were beaten by Chelsea last time out in the league but they showed tremendous heart and courage as they lost 3-2 at Carrow Road.
Daniel Farke's men were unlucky not to grab a point and they have every chance of beating West Ham at the London Stadium.
Bournemouth to beat Leicester City @ 21/5
Although Leicester City are unbeaten this season, they have only won once and that victory came against Sheffield United last weekend.
Brendan Rodgers' men are unbeaten in three at home but the Cherries are known for pulling off shocks in the top flight.
They have only lost to Manchester City so far this season and odds of 21/5 is generous this weekend.