Both teams are expected to challenge for the league title and they were heavy favourites to beat Norwich City and West Ham United last weekend.
Tradition tells us that it is very difficult to predict the early games in the Premier League although there is some value in taking on Chelsea this weekend.
The Blues gave Frank Lampard the job in the summer after Maurizio Sarri left to join Juventus. Lampard put his faith in the club's youngsters on Sunday as his side travelled to Old Trafford to take on Manchester United.
After missing several chances, Chelsea were punished by the Red Devils as they ran out 4-0 winners. United's pace caused Chelsea's defence all sorts of problems and that is why Leicester City need to be considered this weekend.
The Foxes are best priced at odds of 4/1 to beat the Blues and Brendan Rodgers' men need to be taken seriously. Leicester were held to a 0-0 draw against Wolves on Sunday, a decent result considering they had just days to regroup after the sale of Harry Maguire.
Rodgers' side have been handed the toughest start of all in the Premier League but Vardy loves to challenge himself against the 'big boys'.
The former England international should also be considered in the anytime scoring market this weekend.
He is 39/20 to net at Stamford Bridge, while Ayoze Perez will be looking to make a point after a lacklustre performance against Wolves.
The former Newcastle United man admitted he must do more and the winger is 4/1 to find the back of the net anytime in Sunday's battle.