Liverpool will look to extend their winning record to nine matches, while Watford will be doing all they can to climb off the bottom of the table.
But for this week's best player bets we look at other matches in the Premier League.
Everton vs West Ham United - Andriy Yarmolenko to score anytime @10/3
While West Ham went into the international break on the back of a defeat to Crystal Palace, they are still fancied to get a result against Everton.
Manuel Pellegrini's men have only lost one of their last five matches in the top flight, while Everton have lost their last four games.
The pressure is on Marco Silva and punters should look at Yarmolenko to add to his worries. The Ukraine international scored in midweek against Portugal, and he also grabbed a brace in this fixture last season.
Aston Villa vs Brighton - Wesley Moraes to score first @ 13/2
Brighton will look to build on their win over Tottenham Hotspur when they travel to Aston Villa this weekend.
However, Dean Smith's troops are unbeaten in their last three games in all competitions, and they will be brimming with confidence after beating Norwich City 5-1 last time out.
Wesley's brace in that win at Carrow Road took his tally to four goals in eight matches, not a bad return for a player who only joined in the summer.
The Brazilian was not in action over the international break, and he should be fresh and ready to strike this weekend.
Bournemouth vs Norwich - Callum Wilson to score two or more @ 11/2
If the first eight games are anything to go by, then punters should expect plenty of goals between Bournemouth and Norwich.
Eddie Howe's side have always struggled to keep the ball out of their own net, while Norwich were guilty of conceding five goals to Villa.
Teemu Pukki was on song during the international break, but we believe Wilson is the man to watch. The England international has scored five goals in eight games, and he is always dangerous in front of his own fans.