City’s all-time record goalscorer has missed the last three games with a thigh injury and is not yet ready to make a return, although he should be back later this month.
Gabriel Jesus has been starting in Aguero’s absence and the Brazilian ended a 10-game goal drought with a double in the 4-1 win at Burnley in midweek.
Midfielder Ilkay Gundogan missed the win at Turf Moor through suspension but has now served his ban and could come back into the starting XI when United visit the Etihad Stadium.
The hosts remain without long-term injury victims Leroy Sane and Aymeric Laporte.
Manchester United could welcome back French forward Anthony Martial after a minor injury saw him miss Wednesday’s 2-1 win over Spurs at Old Trafford.
Midfielders Nemanja Matic and Paul Pogba are unlikely to be able to feature but both are close to comebacks, while United remain without Eric Bailly and Marcos Rojo.
United have just one win in seven attempts on their travels in the Premier League this season but manager Ole Gunnar Solskjaer says his side can get a result at City after their morale boosting victory over Tottenham.
“Confidence is a strange thing in football; you can get performances and results like Wednesday night and it boosts it so much,” he said. “And I know our boys will be up for it. Twenty-four hours less recovery time [than City, who played on Tuesday] shouldn’t matter, you go on adrenaline.”
United go into the game in sixth spot in the Premier League table and they are eight points adrift of Chelsea in fourth.
City are third, 11 points adrift of current leaders Liverpool after 15 games.