Manchester City 1/3 v Manchester United 10/1 (Sat 17:30 GMT)
City's title hopes are hanging by a thread, with some even suggesting they are no longer in the race after falling nine points adrift of leaders Liverpool.
They have already lost twice and drawn on three occasions, with just 15 games played of the 2019-20 campaign.
A dominant display against Burnley on Tuesday, winning 4-1, put them back on track after a disappointing draw at Newcastle last weekend.
Scoring hasn't been an issue and they lead the way for goals in the division, with 43 to their name.
They have scored at least two goals in all but one of their outings and over 2.5 goals has landed in six of their seven matches at home this term.
That outcome can be backed at 8/15 this weekend and it looks an attractive bet, with both sides likely to be playing on the front foot.
Top scorer Sergio Aguero misses out once again through injury but Gabriel Jesus has proven to be an able deputy.
The Brazilian is priced at 21/20 to score anytime and will be in confident mood after netting twice against the Clarets.
United's away form suggests they could be in for a tough evening when they head to their cross-city rivals.
The Red Devils have picked up just one win on the road since February and their recent record in the derby leaves a lot to be desired.
Both teams to score has landed in six of United's last seven outings, so backing a City win with both to score at 7/4 could be the way to go.