Premier League fans are blessed with huge rivalries with the north London derby, Merseyside derby and Tyne-Wear derby some of the biggest in England.
The North-West derby between Liverpool and Manchester United is one of the most fiercest battles in the game and Sunday's encounter will be no different.
A United victory will not do much to dent Liverpool's title charge, but the Red Devils will want to do anything to end their rival's unbeaten run.
Liverpool's 1-0 win over Tottenham means they have now made the best-ever start to a season by a club in Europe's top five leagues, while United returned to winning ways with a 4-0 success over Norwich City.
We have tried to pick out three of our best bets ahead of the contest.
Half-time/Full-time - Liverpool 6/5
Liverpool have now won their last seven matches in a row, while they have kept a clean sheet in the last six. Jurgen Klopp's side continue to find a way to win, even when they do not play at their best, and it is hard to tip against them nowadays.
An unbeaten season, like Arsenal's Invincibles, has been mentioned but there is still a long way to go for that to happen.
Liverpool will look to set the tempo at home and United may come into the game with some tiredness, as they have an FA Cup replay against Wolves in midweek.
To score 2+ goals - Liverpool 4/9
Liverpool may have scored one goal in three of their last four games, but that should all change this weekend.
Klopp's troops have a full week to prepare for the game and, after a tough few weeks, the rest will do them the world of good.
In front of their own fans, Liverpool will be out for blood, and the form of Sadio Mane, Roberto Firmino and Mohamed Salah will be crucial as they try to grab all three points.
Liverpool to win to nil - 8/5
The form of Marcus Rashford may put some punters off this market, but there is too much evidence to suggest United struggle on the road.
Ole Gunnar Solskjaer's men have failed to score in three of their last four away games, and their inconsistent form suggests 8/5 is a great price to keep another clean sheet on their way to victory.