Six points currently separate the two teams after the first 11 matches, but a close battle is expected on Merseyside.
With both teams possessing great quality, the game could be decided by a moment of magic or an error.
There are also some key head-to-head battles that could go a long way to determining the outcome, and we take a look at some of them.
Raheem Sterling vs Trent Alexander Arnold
Two of England's brightest prospects will face each other this weekend, with Sterling set to play on the left-hand side of midfield. He could be given a licence to roam, but he is expected to come up directly against Alexander-Arnold at Anfield.
The battle between the pair could be fascinating, with Sterling having to work harder than ever to keep Alexander-Arnold inside his own half. The Reds defender has shown his skills going forward throughout this season already but he will also need to keep one eye on Sterling as City try to counter their way towards Liverpool's goal.
Sterling of course faces his former club this weekend, and he is priced at 13/2 to score first.
Sergio Aguero vs Virgil van Dijk
Two of the Premier League's best will come face-to-face on Sunday afternoon as Aguero looks to find a way past Liverpool's defence.
Van Dijk remains the heavy favourite to win the Ballon d'Or after a sensational campaign which saw him lift the Champions League trophy.
However, Aguero has managed to overcome some of the world's best defenders in the last decade, and he will take confidence from Liverpool's recent defensive record.
Jurgen Klopp's men have conceded in their last eight matches, and Aguero is priced at 13/2 to score two or more goals.
Jordan Henderson vs Kevin De Bruyne
Both teams possess plenty of pace across the park, but Liverpool will feel they could win the battle in the middle areas. De Bruyne has looked back to his best so far this season, but Henderson is expected to stalk him for 90 minutes to make sure he doesn't have any time or space on the ball.
The England international has played further forward at times this year, but he may need to do a job on De Bruyne to help his team over the line. Given De Bruyne's obvious talent, he may also need to take one for the team, and Henderson is 15/4 to be shown a yellow card.