It is sure to be an absolute cracker on Merseyside this weekend as league leaders the Reds look to extend their lead over the defending champions to nine points, and there are some intriguing bets ahead of the crucial contest.
Benjamin Mendy to be booked - 13/5
After experiencing horrendous injury luck during his first couple of seasons, France international Mendy has been involved on a more regular basis this term, making three Premier League appearances while featuring in all four Champions League matches.
However, the 25-year-old left-back still looks a little rusty and there have always been concerns over his defensive qualities since his arrival from Monaco in July 2017, which cost the Citizens a reported £52million.
Mendy will have to deal with the formidable attacking trio of Mohamed Salah, Roberto Firmino and Sadio Mane this weekend and if the Frenchman doesn't receive protection from his midfield, it is likely he will end up in the book.
Liverpool to score a penalty - 6/1
There was a huge debate over diving and penalties being awarded last weekend, with Senegal international Mane booked for taking a tumble in the 2-1 win at Aston Villa while Chelsea's Jorginho was harshly adjudged to have given away a penalty in the 2-1 victory over Watford.
Interestingly, City boss Pep Guardiola had a sly dig at Liverpool for how good they are at winning penalties and Mane responded in a joking manner, saying he will dive again if a penalty is on offer.
The Reds have been awarded three spot-kicks in the league this term, leaving them joint-second in the standings with Crystal Palace, and it would be no surprise to see a fourth come their way against City.
Mohamed Salah - First goalscorer - 5/1
Egypt international Salah has once again been in fine scoring form, netting five Premier League goals from 10 appearances, and he has a habit of turning up for this fixture.
The 27-year-old has scored in three of the last five competitive fixtures against the Citizens and he looks well worth a punt at 5/1 to get on the scoresheet first on Sunday.
Having failed to score in his last two outings, Salah will be eager to get back on the goal trail and where better to do so than at home against your title rivals.