The top-two are due to meet in arguably the biggest game of the season to date at Anfield, with the hosts currently sitting six points clear of their rivals at the top of the standings after winning 10 and drawing just one of their opening 11 top-flight games.
Senegal international Mane has been one of the star performers for Jurgen Klopp's team, netting six goals in the league already this season and he is priced at 7/4 to score anytime on Sunday.
It would certainly be no surprise to see Mane have a big say, particularly after the recent comments made by City boss Pep Guardiola, who suggested the 27-year-old has a tendency to dive to win penalties.
Mane responded by jokingly saying he will "dive" again on Sunday, although that could backfire, as match official Michael Oliver may keep a close eye on the former Southampton star, who is priced at 11/2 to be booked anytime.
Mohamed Salah could also be a candidate to score against City. The Egyptian has netted in four of the last seven meetings between the two sides, with each game ending in a Liverpool victory, which means backing the Egyptian to score and Liverpool to win at 3/1 could prove a shrewd choice.
Raheem Sterling is the man of the moment for Manchester City, scoring a staggering 14 goals in 16 games across all competitions so far this term.
The England international bagged one against his former club for the first time during City's penalty shootout triumph in this season's Community Shield and he is priced at 41/20 to be an anytime scorer on Sunday.
Away from goals and City's Fernandinho could be a contender to be carded during the match.
The Brazilian is likely to continue to deputise at the heart of City's defence and he has looked uncomfortable in that role at times, picking up four yellow cards and a red already this season and he is priced at 13/8 to be carded once again this weekend.