It is Jurgen Klopp's Reds, who pushed City all the way last season, who sit top of the pile after four matches as they maintained their unbeaten start with a convincing 3-0 win at Burnley in the later game on Saturday.
The European champions are the only side with a 100 per cent record, while the three-point haul at Turf Moor was a 13th consecutive Premier League win - a new club record - continuing their form from last season's run-in.
Mohamed Salah, Sadio Mane and Roberto Firmino have seven goals between them already and the signs are the trio can fire Liverpool this season.
It seems that the outcome of the title race could depend on the outcome of the games between Liverpool and City this season.
But at a best-price 11/4 to win the title, the Reds offer the best value given that they are the only realistic challengers to City.
Tottenham's 66/1 suggests that they are not in the running and that was reflected by their recent 1-0 home defeat against Newcastle.
Arsenal are also 66s on the back of their 2-2 draw against Spurs in Sunday's north London derby and, while they look a force going forward, their defensive frailties means a top-four finish is probably the height of their ambitions.
Chelsea (125/1) and Manchester United at 150/1 are in a state of transition and could face a fight to remain in contention for the top four or even a top-six finish with possible title bids from them two the stuff of fantasy at present.